陈鹏文，东京大学生物工程学博士，2026年加入深圳理工大学药学院，现任教研助理教授。主要研究生物大分子药物的靶向递送与可编程调控，围绕细胞因子、抗体和核酸等药物分子，开发聚合物载体、化学偶联技术以及刺激响应性递送策略，以实现精准肿瘤免疫治疗。已在 JACS、Angew Chem、Nature Communications、Biomaterials等期刊发表论文30余篇，申请发明专利13项，部分成果已进入转化阶段。

学习经历：

2021-2024 东京大学，生物工程，博士

2019-2021 东京大学，生物工程，硕士

2015-2019 南京大学，化学，学士

工作经历：

2026.10-至今 深圳理工大学，药学院，教研助理教授

2024.10-2026.09 东京大学，生物工程系，博士后

用于细胞因子药物靶向性递送的化学修饰策略开发；用于肿瘤治疗的聚合物-药物偶联系统的开发与转化。

代表性文章

1. P. Chen, G. Hu, Y. Nakashima, Z. Xu, T. Hong, X. Chen, S. Kondo,R. Wolters,H. Yaginuma,S. Takasugi, E. Kovács, H. Cabral, Buffering Cellular Stress during mRNA Delivery Enables Immunoregulatory Interleukin-2 Therapy; Journal of Controlled Release, 399, 115393 (2026).

2. P. Chen#, A. Alhussan#, P. Cullis, H. Cabral, Programmable mRNA Nanotherapeutics through Logic Switch Design; ACS Nano Medicine, In press (2026)

3. K. Suzuki#,P. Chen#, T. Miyazaki#, J. Wan, K. Mizuno, K. Igarashi, K. Kumasawa, Y. Terada, Y. Hirota, Y. Osuga, K. Kataoka, T. Nagamatsu, T. Iriyama, H. Cabral, Defining the Size Threshold of PEGylated Nanomedicines Crossing the Human Placenta Enables Safe Prenatal Therapies; ACS Nano Medicine, In press (2026)

4. P. Chen, G. Hu, W. Yang, Y. Nakashima, Z. Xu, Y. Yang, S. Kondo, X. Chen, S. Takasugi, E. Kovács, K. Fujiu, H. Cabral, Hide-and-seek molecular navigator targets tumor cell surface thiols by programmable disulfide exchange; Biomaterials, 334, 124256 (2026).

5. P. Chen, G. Hu, Y. Nakashima, Z. Xu, T. Watanabe, S. Kondo, E. Kovacs, H. Cabral, Optoregulated mRNA delivery controls pleiotropic immune signaling for tumor-targeted therapy; Angewandte Chemie International Edition, 64, e202513610 (2025).

6. P. Chen, S. Li, K. Nagaoka, K. Kakimi, K. Kataoka, H. Cabral,Nanoenabled IL-15 Superagonist via Conditionally Stabilized Protein-Protein Interactions Eradicates Solid Tumors by Precise Immunomodulation;Journal of the American Chemical Society,146,32431-32444 (2024).

7. P. Chen, H. Cabral,Enhancing Targeted Drug Delivery through Cell-Specific Endosomal Escape;ChemMedChem,19, 202400274 (2024).

8. P. Chen, S. Li, Z. Xu, H. Cabral,Nanoassemblies of Heptamethine Cyanine Dye-Initiated Poly(Amino Acid) Enhance ROS Generation for Effective Antitumour Phototherapy;Nanoscale Horizons, 9, 731-741 (2024).

9. P. Chen, W. Yang, T. Hong, Y. Mochida, H. Kinoh, K. Kataoka, H. Cabral,Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity;Angewandte Chemie International Edition,63,e202317817 (2024)

10. P. Chen, W. K. D. Paraiso, H. Cabral,Revitalizing Cytokine-Based Cancer Immunotherapy through Advanced Delivery Systems;Macromolecular Bioscience,23, 202300275 (2023)

11. P. Chen, W. Yang, K. Nagaoka, G. L. Huang, T. Miyazaki, T. Hong, S. Li, K. Igarashi, K. Takeda, K. Kakimi, K. Kataoka, H. Cabral,An IL-12-based nanocytokine safely potentiates anticancer immunity through spatiotemporal control of inflammation to eradicate advanced cold tumors; Advanced Science,202205139 (2023)

12. M. Panagi#, Fs Mpekris#, P. Chen#, C. Voutouri, Y. Nakagawa, J. Martin, T. Hiroi, H. Hashimoto, P. Demetriou, C. Pierides, R. Samuel, A. Stylianou, C. Michael, S. Fukushima, P. Georgiou, P. Papageorgis, P. Papaphillipou, L. Koumas, P. A. Costeas, G. Ishii, M. Kojima, K. Kataoka, H. Cabral, T. Stylianopoulos; Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models;Nature Communications,13, 7165 (2022)

13. P. Chen, W. Yang, T. Hong, T. Miyazaki, A. Dirisala, K. Kataoka, H. Cabral; Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC;Biomaterials, 288,121748 (2022)

代表性成果转化

在细胞因子药物的化学修饰，蛋白质与核酸递送等方向已累计申请发明专利13项，其中9项已公开：

1. Live cell encapsulation; WO/2025/229172

2. Selective intracellular delivery of protein in cells with nanocarriers sensing cathepsin B activity; WO/2025/164814

3. pH-responsive protein delivery carrier; PCT/JP2024/080028

4. Polymer micelle pharmaceutical for nano immunotherapy; JP2024035494

5. Nucleic acid closing polymeric micelle; WO/2023/238961

6. Protein-enclosing polymeric complexes; US Patent App. 63/571,420

7. Cytokine-encapsulating polymeric micelle; WO/2023/136364

8. Nicotinamide-encapsulating micelles, and pregnancy-induced hypertension syndrome therapy composition containing nicotinamide-encapsulating micelles; WO/2022/075470

9. Protein-enclosing polymeric micelle; WO/2020/262550

其中，关于细胞因子蛋白质的聚合物修饰策略的专利（WO/2020/262550；WO/2023/136364）已转化为美国Red Arrow Therapeutics公司的核心研发产品管线。

电子邮箱：chenpengwen@suat-sz.edu.cn