研究员/博导，中国科学院深圳先进技术研究院医药所精准组织工程课题组组长，国家优青（生命科学，2021），中国科学院青年促进创新委员会优秀会员（2023），广东省科技创新青年拨尖人才（2015）。聚焦于生物3D打印与组织/器官重建的新材料、新技术及新策略交叉前沿科学研究，研发了系列功能生物打印材料体系，兼顾可打印性、力学行为及生物活性等关键因素，突破了当前生物3D打印技术的宏微观尺度及精准性，仿生组装多种复杂组织/器官及实现其功能重建。先后主持国家自然科学基金项目（5项），科技部国家重点研发计划战略性科技合作专项及纳米前沿专项等。
学习经历：
2007.9-2011.12 重庆大学 生物医学工程博士
2003.9-2007.6 重庆大学 生物工程学士
工作经历：
2020.1-现在 中国科学院深圳先进技术研究院医药所研究员
2015.1-2019.12 中国科学院深圳先进技术研究院医药所副研究员
2014.1-2015.1 香港大学玛丽医院创伤与矫形外科访问学者
2012.3-2014.12 中国科学院深圳先进技术研究院医药所助理研究员
承担项目：
(1)国家自然科学基金优秀青年项目，32122046，生物3D打印骨再生材料，2022.1.1-2024.12.31，200万，主持；
(2)国家重点研发计划，国家重点研发计划战略性科技合作, 2023YFE0210500,生物3D打印人关节芯片用于骨关节炎药物筛选及个性化治疗, 2024-01至2025-12, 200万元,主持；
(3)国家重点研发计划，2022YFA1207502，仿生梯度关节软骨预构体的3D生物打印技术及装备研发，2023.5.1-2028.4.30，459万，课题负责人；
(4)国家自然科学基金面上项目，82072082，仿骨-软骨差异性功能微环境的一体化支架生物3D打印构建及其促再生机制研究，2021-01至2024-12，55万，主持；
(5)国家自然科学基金面上项目，31771041，聚氨酯基骨修复材料降解行为的动态示踪及其调控骨再生的机制研究，2018-01至2021-12，60万，主持；
[1]Jirong Yang; Zhigang Chen; Chongjian Gao; Juan Liu; Kaizheng Liu; Xiao Wang; Xiaoling Pan; Guocheng Wang; Hongxun Sang; Haobo Pan; Wenguang Liu; Changshun Ruan*; A mechanical-assisted post-bioprinting strategy for challenging bone defects repair.Nature Communications,15(2024):3565. (Featured article)
[2]Huawei Qu; Chongjian Gao; Kaizheng Liu; Hongya Fu; Zhiyuan Liu; Paul H. J. Kouwer ; Zhenyu Han; Changshun Ruan*; Gradient matters via filament diameteradjustable 3D printing.Nature Communications,15(2024):2930.
[3]Yijian Zhang#; Duo Li#; Yang Liu#; Liuqi Peng; Dongdong Lu; Pinpin Wang; Dongxu Ke; Huilin Yang*; Xuesong Zhu*;Changshun Ruan*;3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage-bone interface.The Innovation, 2024,5(1), 100542.
[4]Chongjian Gao#; Lan Tang#; Huawei Qu; Mingming Wu; Tian Zhou; Chunyi Wen; Pinpin Wang*; Nan Xu*; andChangshun Ruan*; A Small-Molecule Polycationic Crosslinker Boosts Alginate-Based Bioinks for Extrusion Bioprinting.Advanced Functional Materials,2023, 2310369.
[5]Qingfei Liang,Fei Gao,Zhiweng Zeng,Jirong Yang,Mingming Wu,Chongjian Gao,Delin Cheng,Haobo Pan*,Wenguang Liu*,Changshun Ruan*. Coaxial Scale-up Printing of Diameter-tunable Biohybrid Hydrogel Microtubes with High Strength, Perfusability and Endothelialization.Advanced Functional Materials, 2020, 30, 2001485.
[6]Zifeng Lin, Mingming Wu, Huimin He, Qingfei Liang, Chengshen Hu, Zhiwen Zeng, Delin Cheng, Goucheng Wang, Dafu Chen, * Haobo Pan, * andChangshun Ruan *. 3D Printing of Mechanically Stable Calcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to Enable Cell Adhesion and Facile Biofunctionalization,Advanced Functional Materials, 2019, 29(9), 1808439.
[7]Fei Gao , Ziyang Xu , Qingfei Liang, Haofei Li, Liuqi Peng , Mingming Wu , Xiaoli Zhao , Xu Cui,Changshun Ruan*and Wenguang Liu *. Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds,Advanced Science, 2019, 15(6), 1900867.
[8]Fei Gao , Ziyang Xu, Qingfei Liang, Bo Liu , Haofei Li, Yuanhao Wu, Yinyu Zhang, Zifeng Lin, Mingming Wu,Changshun Ruan*, Wenguang Liu *, Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect,Advanced Functional Materials, 2018, 1706644.
[9]Xinyun Zhai ,Changshun Ruan*, Yufei Ma , Delin Cheng, Mingming Wu , Wenguang Liu, Xiaoli Zhao, Haobo Pan*, William Weijia Lu *, 3D-bioprinted Osteoblast-laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation and Osteogenesis both In Vitro and In Vivo,Advanced Science, 2018, 3:201700550.
[10]Zhijian Zhao, Xiaowei Xia, Junlin Liu, Mingzhuang Hou, Yang Liu, Zhangzhe Zhou, Yong Xu, Fan He, Huilin Yang, Yijian Zhang*,Changshun Ruan*, Xuesong Zhu*, Cartilage-inspired self-assembly glycopeptide hydrogels for cartilage regeneration via ROS scavenging,Bioactive Materials,32 (2024): 319-332.
