成果转化情况：
授权发明专利28项，其中13项专利已转让企业（无形资产入股作价666万）。孵化科技成果转化企业三家，取得了科技部生物材料与植入器械创新示范基地建设项目，作为联合创始人，发起生物材料成果转化天使基金，已投资生物材料初创企业8家。
重大科技项目承担情况：
(1)国家自然科学基金委员会,国际(地区)合作与交流项目, 32161160327,硼硅酸盐生物活性玻璃介导骨再生微环境及其抑制骨肿瘤机制研究, 2022-01-01至2025-12-31, 100万元,在研,主持；
(2)国家自然科学基金委员会,联合基金项目, U2001221,生物打印多级仿生骨修复体及微营养通道构建, 2021-01-01至2024-12-31, 260万元,在研,主持；
(3)国家自然科学基金委员会,面上项目, 31870956,碱性微环境成骨开关效应：动态环境中可降解生物活性材料表面微碱性梯度形成及成骨机制研究, 2019-01-01至2022-12-31, 59万元,结题,主持；
(4)深圳市医学科学院,前沿探索型一般项目, B2302031,双体系微创植入骨修复材料开发及骨代谢调控机制与评价, 2024-01至2026-12, 300万元,在研,主持；
(5)广东省科学技术厅,粤佛联合基金重点项目, 2022B1515120048,多级纳米生物活性玻璃的设计制备及其体内应用监测研究, 2022-10至2025-09, 100万元,在研,主持；
(6)国家科技部,重点研发计划项目, 2021YFC2400500,基于微环境定向调控可抑制骨与皮肤肿瘤复发的生物活性材料研制, 2021-12至2024-11, 1500万元,在研,主持。
1.Jua Kim,Haobo Pan*.Effects of Magnesium Alloy Corrosion on Biological Response- Perspectives of Metal-Cell Interaction.Progress in Materials Science.2023;133:101039(Q1,IF:37.4)
2.Pengfei Tian; Liming Zhao; Jua Kim; Xian Li; Chunyu Liu; Xu Cui; Tao Liang; Yunbo Du;Xiehui Chen;Haobo Pan*; Dual stimulus responsive borosilicate glass (BSG) scaffolds promotediabetic alveolar bone defects by modulating macrophage phenotype, Bioactive Materials, 2023, 26:231-248(Q1,IF=18.9）
3.Yang, Minggang; Qiu, Shi; Coy, Emerson; Li, Shuaijie; Zaleski, Karol; Zhang, Yao*;Pan, Haobo*; Wang, Guocheng*. NIR-responsive TiO2 Biometasurface: Towards in situ Photodynamic Antibacterial Therapy for Biomedical Implants.Advanced Materials. 2022;34:e2106314(Q1,IF:29.4)
4.Shuaijie Li, Liyan Zhang, Chunyu Liu, Jua Kim, Kun Su, Tingli Chen, Limin Zhao, Xiaomei Lu, Hao Zhang, Yinglin Cui, Xu Cui*, Feng Yuan*,Haobo Pan*. Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects.Bioactive Materials2023;23:101-117(Q1,IF=18.9)
5.Chunyu Liu # , Xu Cui# , Yunbo Du # , Xue Wang, Jua Kim, Shuaijie Li, Liyan Zhang, Xiaoli Zhao, Limin Zhao, Pengfei Tian, Hao Zhang, Kun Su, Xian Li,Haobo Pan*. Unusual surface coagulation activation patterns of crystalline and amorphous silicate-based biominerals.Adv Healthcare Mater. 2023;DOI: 10.1002/adhm.202300039(Q1,IF:10)
6.Shaoquan Bian, Liuzhi Hao, Xin Qiu, Jun Wu, Hao Chang, Guan-Ming Kuang, Sheng Zhang, Xiaohua Hu, Yakang Dai, Zhiyong Zhou, Fangli Huang, Chun Liu, Xuenong Zou, Wenguang Liu, Willima W. Lu,Haobo Pan*, Xiaoli Zhao*. An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing.Advanced Functional Materials2022;32: 2207741(Q1,IF:19)
7.Hao Zhang; Yinglin Cui; Xianglong Zhuo; Jua Kim; Honglong Li; Shuaijie Li; Hongsheng Yang; Kun Su; Chunyu Liu; Pengfei Tian; Xian Li; Li Li; Deping Wang; Limin Zhao; Jianyun Wang; Xu Cui*; Bing Li*; andHaobo Pan*. Biological Fixation of Bioactive Bone Cement in Vertebroplasty: The First Clinical Investigation of Borosilicate Glass (BSG) Reinforced PMMA Bone Cement.ACS Applied Materials & Interfaces. 202223;14(46):51711-51727(Q1,IF:9.5)
8.Pang, Libin; Zhao, Renliang; Chen, Jing; Ding, Jingxin; Chen, Xiaochen; Chai, Wenwen; Cui, Xu; Li, Xiaolin*; Wang, Deping*;Pan, Haobo*.Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment.Bioactive Materials. 2022;12:1-15(Q1,IF=18.9)
9.Hao Zhang；Li Li；Lei Chu；Jing Huang；Xiaochen Chen；Xianglong Zhuo；Yulin Wang；John Robert Honiball；Bin Wang；Wei Chen；William W. Lu；Deping Wang；Bing Li**；Xu Cui***；Haobo Pan*.Dual-functional borosilicate glass (BSG) delivery implant for osteomyelitis treatment and bone regeneration.Composites Part B: Engineering. 2023,259,110749(Q1,IF:13.1)
10.Liang, Tao; Zeng, Lilan; Shi, Yunzhu;Pan, Haobo*; Chu, K. Paul; Yeung, W.K. Kelvin*; Zhao, Ying*. In vitro and in vivo antibacterial performance of Zr & O PIII magnesium alloys with high concentration of oxygen vacancies.Bioactive Materials. 2021;6(10):3049-3061(Q1,IF=18.9)
11.Yongkang Huang, Xinyun Zhai*, Tengfei Ma, Mengzhen Zhang, Houzhi Yang, Shuai Zhang, Junbo Wang, Wenguang Liu, Xin Jin, William Weijia Lu, Xiaoli Zhao, Weiyu Hou, Tianwei Sun, Jie Shen,Haobo Pan*, Yaping Du*, Chun-Hua Yan. A Unified Therapeutic–Prophylactic Tissue-Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling.Advanced Materials.2023,35, 2300313(Q1,IF:29.4)
12.Cui, Xu; Huang, Chengcheng; Chen, Zhizhen; Zhang, Meng; Liu, Chunyu; Su, Kun; Wang, Jianyun; Li, Li; Wang, Renxian; Li, Bing; Chen, Dafu; Ruan, Changshun; Wang, Deping; Lu, William W.;Pan, Haobo*. Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression.Bioactive Materials. 2021;6(11): 3801-3811(Q1,IF=18.9)
13.Liang, Qingfei; Gao, Fei; Zeng, Zhiwen; Yang, Jirong; Wu, Mingming; Gao, Chongjian; Cheng, Delin;Pan, Haobo*; Liu, Wenguang*; Ruan, Changshun*. Coaxial Scale-Up Printing of Diameter-Tunable Biohybrid Hydrogel Microtubes with High Strength, Perfusability, and Endothelialization.Advanced Functional Materials. 2020;30:2001485(Q1,IF:19)
14.Tao Liang; Huanhuan Zhang;Haobo Pan*; Ying Zhao*. Insight into microbiologically induced corrosion performance of magnesium in tryptic soy broth with S. aureus and E. coli.Journal of Materials Science & Technology. 2022;115: 221-231(Q1,IF:10.9)
15.Huawei Qu; Zhenyu Han; Zhigang Chen; Lan Tang; Chongjian Gao; Kaizheng Liu;Haobo Pan*; Hongya Fu*; Changshun Ruan*. Fractal design boosts extrusion-based 3D printing of bone-mimicking radial-gradient scaffolds.Research. 2021;9892689(Q1,IF:11)
16.Zifeng Lin; Mingming Wu; Huimin He; Qingfei Liang; Chengshen Hu; Zhiwen Zeng; Delin Cheng; Guocheng Wang; Dafu Chen * ;Haobo Pan*; Changshun Ruan*. 3D printing of mechanically stable calcium-free alginate based scaffolds with tunable surface charge to enable cell adhesion and facile biofunctionalization.Advanced Functional Materials. 2019; 29(9):1808439(Q1,IF:19)
17.Xu Cui; Yadong Zhang; Jianyun Wang; Chengcheng Huang; Yudong Wang; Hongsheng Yang; Wenlong Liu; Ting Wang; Deping Wang; Guocheng Wang; Changshun Ruan; Dafu Chen * ; William W Lu; Wenhai Huang; Mohamed N. Rahaman*,Haobo Pan*. Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway.Bioactive Materials. 2020;5(2):334-347(Q1,IF=18.9)
18.Pang, Libin; Tian, Pengfei; Cui, Xu; Wu, Xiuping; Zhao, Xiaoli; Wang, Hui; Wang, Deping*;Pan, Haobo*. In Situ Photo-Cross-Linking Hydrogel Accelerates Diabetic Wound Healing through Restored Hypoxia-Inducible Factor 1-Alpha Pathway and Regulated Inflammation.ACS Applied Materials & Interfaces.2021;13(25): 29363-29379(Q1,IF:9.5)
19.Wenlong Liu; Xiuli Dan; William W Lu; Xiaoli Zhao; Changshun Ruan; Ting Wang; Xu Cui; Xinyun Zhai; Yufei Ma; Deping Wang; Wenhai Huang;Haobo Pan*. Spatial distribution of biomaterial microenvironment pH and its modulatory effect on osteoclasts at the early stage of bone defect regeneration.ACS Applied Materials & Interfaces.2019;9(11):9557-9572(Q1,IF:9.5)
20.Xinyun Zhai; Changshun Ruan*; Yufei Ma; Delin Cheng; Mingming Wu; Wenguang Liu; Xiaoli Zhao;Haobo Pan*; William Weijia Lu*. 3D-bioprinted osteoblast-Laden nanocomposite hydrogel constructs with induced microenvironments promote cell viability, differentiation, and osteogenesis both in vitro and in vivo.Advanced Science. 2017;5(3): 1700550(Q1,IF:15.1)
21.Wenlong Liu; Ting Wang; Xiaoli Zhao; Xiuli Dan; William W Lu;Haobo Pan*. Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect.Bioactive Materials. 2016;1(2):151-159(Q1,IF=18.9)
22.Yanqun Li; Jianhui Yue; Yuan Liu; Jun Wu; Min Guan; Di Chen;Haobo Pan*; Xiaoli Zhao*; William W. Lu. Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division.Acta Biomaterialia.2021;119:432-443(Q1,IF:9.7)
23.Weibin Zhang # ; Yuhui Shen # ;Haobo Pan*; Kaili Lin; Xiaoguo Liu; Brian W Darvell; William W Lu; Jiang Chang; Lianfu Deng; Deping Wang; Wenhai Huang. Effects of strontium in modified biomaterials.Acta Biomaterialia2011;2(7):800-808(Q1,IF:9.7)
24.Pengfei Tian # , Liming Zhao # , Jua Kim, Xian Li, Chunyu Liu, Xu Cui, Yunbo Du, Xiehui Chen,Haobo Pan*. Dual stimulus responsive borosilicate glass (BSG) scaffolds promote diabetic alveolar bone defects by modulating macrophage phenotype.Bioactive Materials. 2023;26:231-248.(Q1,IF=18.9)
25.Haobo Pan; Zhaoyang Li; Raymond Lam; JC Wong; Brian W Darvell; Keith Dip-Kei Luk; William W Lu*. Solubility of strontium-substituted apatite by solidtitration.Acta Biomaterialia2009;5(5):1678-1685(Q1,IF:9.7)
26.Haobo Pan; Xiaoli Zhao; Brian W Darvell*; William W Lu*. Apatite-formation ability - predictor of "bioactivity"?.Acta Biomaterialia.2010;11(6):4181-4188 (Q1,IF:9.7)
27.Tongtong Zang, Han Chen, Shutong Shen, Fei Xu, Rui Wang, Jia Yin, Xiehui Chen, Min Guan, Li Shen*,Haobo Pan*, and Junbo Ge*. Highly Purified Eicosapentaenoic Acid Alleviates the Inflammatory Response and Oxidative Stress in Macrophages during Atherosclerosis via the miR-1a-3p/sFRP1/Wnt/PCP-JNK Pathway.Oxidative Medicine and Cellular Longevity. 2022;9451058(Q2,IF: 7.31)
28.Yuhui Shen # ; Waiching Liu # ; Chunyi Wen;Haobo Pan*; Ting Wang; Brian W Darvell; William W Lu; Wenhai Huang. Bone regeneration: importance of local pH-strontium-doped borosilicate scaffold.Journal of Materials Chemistry2012;17(22):8662-8667 (IF: 7.571)
29.Zhai, Xinyun; Ruan, Changshun * ; Shen, Jie; Zheng, Chuping; Zhao, Xiaoli;Pan, Haobo*; Lu, William Weijia*. Clay-based nanocomposite hydrogel with attractive mechanical propertiesand sustained bioactive ion release for bone defect repair.Journal of Materials Chemistry B. 2021;9:2309-2406 (IF: 7.571)
30.Shaoquan Bian; Zhiqiang Zheng; Yuan Liu; Changshun Ruan;Haobo Pan*; Xiaoli Zhao*. A shear-thinning adhesive hydrogel reinforced by photo-initiated crosslinking as a fit-to-shape tissue sealant.Journal of Materials Chemistry B. 2019;42(7):6488-6499 (IF: 7.571)
31.Qingchang Chen; Jun Wu; Yuan Liu; Yanqun Li; Chuqiu Zhang; Weichen Qi; Kelvin W K Yeung; Tak Man Wong; Xiaoli Zhao*;Haobo Pan*. Electrospun chitosan/PVA/bioglass nanofibrous membrane with spatially designed structure for accelerating chronic wound healing.Materials Science and Engineering C. 2019;105:110083 (IF: 7.328)
32.Xu Cui; Wenhai Huang; Yadong Zhang*; Chengcheng Huang; Zunxiong Yu; Lei Wang; Wenlong Liu; Ting Wang; Jie Zhou; Hui Wang; Nai Zhou; Deping Wang;Haobo Pan*; MohamedN Rahaman*. Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model.Materials Science and Engineering C.2017; 73:585-595 (IF: 7.328)
33.Hao Chang#, Pengfei Tian#, Liuzhi Hao, Chengwei Hu, Bo Liu, Fengzhen Meng, Xin Yi, Xiaohua Pan, Xiaohua Hu, Huan Wang, Xinyun Zhai, Xu Cui, Jason Pui Yin Cheung, Xuanyong Liu,Haobo Pan*, Shaoquan Bian*, Xiaoli Zhao*. Antioxidative bioactive glass reinforced injectable hydrogel with reactive oxygen species scavenging capacity for diabetic wounds treatment.Chemical Engineering Journal. 2024; 481:148768 (IF: 15.1)
34.Wenwen Chai , Xiaochen Chen, Jing Liu , Liyan Zhang , Chunyu Liu, Li Li, John Robert Honiball ,Haobo Pan*, Xu Cui*,and Deping Wang*.Recent progress in functional metal–organic frameworks for bio-medical application.Regenerative Biomaterials, 2024, 11, rbad115 (IF: 6.7)
35.Xiaochen Chen,Liyan Zhang,Wenwen Chai,Pengfei Tian,Jua Kim,Jingxin Ding,Hao Zhang,Chunyu Liu,Deping Wang*,Xu Cui*,Haobo Pan*. Hypoxic microenvironment reconstruction with synergistic biofunctional ions promotes diabetic wound healing.Advanced Healthcare Materials.2023:202301984(IF: 10)
