郑植元，博士，深圳理工大学药学院科研助理教授，入选深圳市重点人才计划。主要从事抗体类、CAR-T、TCR-T等生物技术药物的研发，以及天然小分子药物的发现、结构优化与药理活性研究。

学习经历：

2017-2021，澳门科技大学，中药机制与质量全国重点实验室，中药学，博士

2012-2015，中国科学院大学，中药学，硕士

2008-2012，郑州大学，药学，学士

工作经历：

2023-至今，深圳理工大学药学院，科研助理教授

2021-2023，中国科学院深圳先进技术研究院，博士后/助理研究员

2016-2017，澳门科技大学，中药机制与质量全国重点实验室，科研助理

2015-2016，河南省医药科学研究院，河南省肝病药理重点实验室，研究实习员

主要从事靶向实体肿瘤的小分子药物和工程化细胞药物研究与开发；参与国家自然科学基金重点项目和面上项目、国家重点研发计划项目、澳门科技发展基金项目等；发表论文20余篇，申请发明专利6项，授权3项；荣获2014年硕士研究生国家奖学金、2019年中国化学会第十一届全国化学生物学学术会议最佳博士生报告奖。

1.肿瘤免疫疗法新技术研究；

2.天然小分子药物的发现、结构优化与药理活性研究

1.Liu, M.^#,Zheng, Z.^#, Zhang, Y., Bian, X., Zhuo, Y., Wu, H. Y., Wu, J. L.*, Li, N.*.Chemical Proteomics Reveals Sinomenine’s Anti-inflammatory Mechanism through Serum Protein Covalent Modification,Chin Med,2026, 21(1), 124.

2.Zheng, Z.^#, Xu, T.^#, Liu, Z., Tian, W., Jiang, Z. H., Zhu, G. Y., Li, T., Gao, J., Bai, L. P.*.Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis,Biomed Pharmacother, 2022, 153, 113319.

3.Zheng, Z.^#, Zhou, Z.^#, Zhang, Q., Zhou, X., Yang, J., Yang, M. R., Zhu, G. Y., Jiang, Z. H., Li, T., Lin, Q., Bai, L. P.*.Non-classical cardenolides fromCalotropis giganteaexhibit anticancer effect as HIF-1 inhibitors,Bioorg Chem, 2021, 109, 104740.

4.Zheng, Z.^#, Zhang, M.^#, Xiao, Y., Wei, L.*, Li, C.*.Effect of Cys, GSH, and pH on Mercury Release from Tibetan MedicineZuotai, β-HgS, and α-HgS in Artificial Gastrointestinal Juices,Biol Trace Elem Res, 2018, 184(2):536-545.

5.Zheng, Z. Y., Du, Y. Z., Zhang, M., Yu, M. J., Li, C., Yang, H. X., Zhao, J., Xia, Z. H., Wei, L. X.*. Study on Content Determination of Lead and Arsenic in Four Traditional Tibetan Medicine Prescription Preparations by Wet Digestion Flow Injection-Hydride Generation-Atomic Absorption Spectrometry,Spectrosc Spect Anal, 2015, 35(4):1037-1042.

6.Liu, M.^#, Ning, Z.^#, Cheng, Y.,Zheng, Z., Yang, X., Zheng, T., Li, N.*, Wu, J. L.*.The key to 2,6-dichloro-1,4-benzoquinone reproductive toxicity and green tea detoxification: Covalent binding and competitive binding,Ecotoxicol Environ Saf, 2024, 286, 117239.

7.Liu, M., Huang, H., Bian, X.,Zheng, Z., Li, N., Sun, B.*,Wu, J. L.*. A prospective cohort study of the presence of SARS-CoV-2 in clinical samples from multiple bodily sites: implications for transmission routes of COVID-19,J Bio-X Res, 2022, 5(1): 27-34.

8. Guo, Y.^#, Meng, J. R.^#, Liu, J. Z., Xu, T.,Zheng, Z. Y., Jiang, Z. H., & Bai, L. P.*. Synthesis and Biological Evaluation of Honokiol Derivatives Bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones as Potential Viral Entry Inhibitors against SARS-CoV-2,Pharmaceuticals, 2021, 14(9), 885.

9.Xu, T.,Zheng, Z., Guo, Y.*, Bai, L. P.*.Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy,Eur JMed Chem, 2020, 205, 112663.

10.Liu, M., Li, N.*, Zhang, Y.,Zheng, Z., Zhuo, Y., Sun, B., Bai, L. P., Zhang, M., Guo, M. Q., Wu, J. L.*.Characterization of covalent protein modification by triclosan in vivo and in vitro via three-dimensional liquid chromatography-mass spectrometry: New insight into its adverse effects,Environ Int, 2020, 136, 105423.

11. Zhou, X.^#, Qu, Y. Q.^#,Zheng, Z., Law, B. Y. K., Mok, S. W. F., Jiang, Z. H., Wong, V. K. W.*, Bai, L. P.*.Novel dauricine derivatives suppress cancer via autophagy-dependent cell death,Bioorg Chem, 2019, 83: 450-460.

12.Fan, D., Li, T.,Zheng, Z., Zhu, G. Y., Yao, X., Jiang, Z. H.*, Bai, L. P.*.Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii,J Nat Med, 2019, 73(1):23-33.

13. Li, C., Xu, W., Chu, S.,Zheng, Z., Xiao, Y., Li, L., Bi, H., Wei, L.*. The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicineZuotai，β-HgS and HgCl₂in mouse kidney,J Trace Elem Med Biol, 2018, 45: 104-113.

14.Zhou, X.^#,Chen, M.^#,Zheng, Z., Zhu, G. Y.,Jiang, Z. H.*, Bai, L. P.*. Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity,RSC Adv, 2017, 7, 26921-26929.

15. Fan, D., Zhou, S.,Zheng, Z., Zhu, G. Y., Yao, X., Yang, M. R., Jiang, Z. H., Bai, L. P. *. New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii,Int J Mol Sci, 2017, 18(1), 147.

电子邮件：zhengzhiyuan@suat-sz.edu.cn