师资队伍

夏厚军Houjun Xia

教研助理教授

药学院

前海外职称:密歇根大学医学院,博士后

邮箱:xiahoujun@suat-sz.edu.cn

不积跬步,无以至千里;不积小流,无以成江海——荀子《劝学篇》

个人简介

夏厚军,2004年毕业于武汉大学生命科学学院;2010年毕业于中国科学院昆明动物研究所分子免疫药理学实验室,获得动物学博士学位;2010年至2014年在昆明动物所肿瘤生物学实验室任助理研究员;2014年至2021年在美国密歇根大学医学院外科系进行博士后研究。2021年入职深圳理工大学和中国科学院深圳先进技术研究院。曾先后主持国家自然科学面上基金和青年基金项目,中国科学院“西部之光“人才项目以及863计划子课题项目。曾荣获2016年美国免疫学年会摘要奖和2019年Moses Gunn会议最佳墙报奖。迄今为止累计发表论文39篇,引用超过6100多次,H指数为23(Google Scholar)。其中以第一作者或通讯作者在Science Immunology, Nature Reviews Cancer,和JCI insight等SCI杂志上共发表论文19篇,在利用动物模型探索肿瘤免疫逃逸机制和自噬调控肿瘤微环境等方面取得一系列创新性成果。

课题组网站:https://fps.suat-sz.edu.cn/XiaHoujunLab/

学习工作经历

学习经历:

2004-2010,中国科学院昆明动物研究所,博士

2000-2004,武汉大学生命科学院,学士

工作经历:

2021-至今,深圳理工大学药学院,助理教授;

中国科学院深圳先进技术研究院医药所癌症免疫中心,副研究员

2014-2021,密歇根大学医学院,博士后

2010-2014,中国科学院昆明动物研究所,助理研究员

所获荣誉

2019年云南省自然科学奖三等奖 陈策实、梁斌、夏厚军,“乳腺癌及代谢性疾病树鼩模型的创建与研究”

2010年中国科学院地奥奖学金二等奖

研究领域

1.免疫细胞自噬对肿瘤免疫反应的调控;

2.组织常驻巨噬细胞促进肿瘤免疫逃逸的机制研究;

3.靶向自噬在肿瘤免疫治疗中的协同作用。

代表性论文

1. Lu Z, Bi J*, Zheng C, Cui L,Xia H, Wan X*, Chen YH*. Tumor Cell AMPK Activation Enhances NK Cell Anti-tumor Immunity and Synergizes with PD-L1 Blockade Therapy. Molecular Therapy. 2026; S1525-0016(26)00033-X.

2. Tan J, Zhao L, Li M, Yang K, Li Y, Ding Y, Liu H,Xia H*, Wang C*, Li J*. Structure-guided design of a minimal epitope tag and nanobody affinity system. Journal of Chromatography A. 2026; 466675.

3. Zeng F, Chen C, Fu Z, Huang H, Cui W, Zhou Y, Kong Y, Liu X, Xu Z, Wang S*, Xiao T*,Xia H*. A novelβ-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression. Cellular Oncology. 2025; 1-16.

4. Shahzadi I, Ahsan T, Anwaar S, Zaman W,Xia H*. Promoter Hypomethylation Unleashes HMGA1 to Orchestrate Immune Evasion and Therapy Resistance Across Cancers. Biology. 2025;14 (12), 1758.

5. Tan H, Cai M, Wang J, Yu T,Xia H*, Zhao H*, Zhang X*. Harnessing macrophages in cancer therapy: from immune modulators to therapeutic targets. International Journal of Biological Sciences. 2025; 21 (5), 2235.

6. Mauki DH, Li P, Lang S, Kong Y, Babarinde IA, Samuel OW,Xia H, Chen YH*. Unveiling TNFAIP8L2-related immune evasion mechanisms in colorectal cancer. Computational and Structural Biotechnology Reports. 2025;2:100041.

7. Choi JE, Qiao Y, Kryczek I, Yu J, Gurkan J, Bao Y, Gondal M, Tien JC, Maj T, Yazdani S, Parolia A,Xia H, Zhou J, Wei S, Grove S, Vatan L, Lin H, Li G, Zheng Y, Zhang Y, Cao X, Su F, Wang R, He T, Cieslik M, Green MD, Zou W*, Chinnaiyan AM*. PIKfyve, expressed by CD11c-positive cells, controls tumor immunity. Nat Commun. 2024;15(1):5487.

8. Chen X, Lu Z, Xiao J, Xia W, Pan Y,Xia H, Chen YH*, Zhang H*. Small-Molecule Inhibitors of TIPE3 Protein Identified through Deep Learning Suppress Cancer Cell Growth In Vitro. Cells. 2024;13(9):771.

9. Pitter MR, Kryczek I, Zhang H, Nagarsheth N,Xia H, Wu Z, Tian Y, Okla K, Liao P, Wang W, Zhou J, Li G, Lin H, Vatan L, Grove S, Wei S, Li Y, Zou W*. PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages. Cell Rep. 2024;43(3):113942.

10. Yang L, Liu J, Guo W, Zheng Z, Xu Y,Xia H*, Xiao T*. Insights into the multi-chromosomal mitochondrial genome structure of the xero-halophytic plant Haloxylon Ammodendron (C.A.Mey.) Bunge ex Fenzl. BMC genomics. 2024;25 (1), 123.

11. Chen X, Li Y,Xia H*, Chen YH*. Monocytes in Tumorigenesis and Tumor Immunotherapy. Cells. 2023;12 (13), 1673

12.Xia H*, Chen YH*. How sugar instigates macrophages to be evils in tumor. Cellular & Molecular Immunology. 2022; 19 (12), 1325-1327.

13. Zhang Y, Ouyang D, Chen YH,Xia H*. Peritoneal resident macrophages in tumor metastasis and immunotherapy. Front Cell Dev Biol. 2022;10:948952.

14. Li F, Liang H, You H, Xiao J,Xia H, Chen X, Huang M, Cheng Z, Yang C, Liu W, Zhang H, Zeng L, Wu Y, Ge F, Li Z, Zhou W, Wen Y, Zhou Z, Liu R, Jiang D, Xie N, Liang B, Liu Z, Kong Y, Chen C*. Targeting HECTD3-IKKαaxis inhibits inflammation-related metastasis. Signal Transduct Target Ther. 2022;7(1):264.

15.Xia H, Green DR*, and Zou W*. Autophagy in tumour immunity and therapy (Review). Nat Rev Cancer. 2021;21:281–297.

16. Lin H, Kryczek I, Li S, Green MD, Ali A, Hamasha R, Wei S, Vatan L, Szeliga W, Grove S, Li X, Li J, Wang W, Yan Y, Choi JE, Li G, Bian Y, Xu Y, Zhou J, Yu J,Xia H, Wang W, Alva A, Chinnaiyan AM, Cieslik M, Zou W*. Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. Cancer Cell. 2021;39(4):480-493.e6.

17. Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu Z, Zhang L, Czerwonka A, Pawłowska A,Xia H, Li J, Liao P, Yu J, Vatan L, Szeliga W, Wei S, Grove S, Liu JR, McLean K, Cieslik M, Chinnaiyan A, Zgodziński W, Wallner G, Wertel I, Okła K, Kryczek I, Lyssiotis CA, Zou W*. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020;585(7824):277-282.

18.Xia H, Li S, Li X, Wang W, Bian Y, Wei S, Grove S, Wang W, Vatan L, Liu JR, McLean K, Rattan R, Munkarah AR, Guan JL, Kryczek I, Zou W*. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. JCI insight. 2020;5(18):141115.

19. Wang W, Green M, Choi J, Gijón M, Kennedy P, Johnson J, Liao P, Lang X, Kryczek I, Sell A,Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence T, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan T, Chinnaiyan A, Zou W*. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270-274.

20. Li W, Tanikawa T, Kryczek I,Xia H, Li G, Wu K, Wei S, Zhao L, Vatan L, Wen B, Shu P, Sun D, Kleer C, Wicha M, Sabel M, Tao K, Wang G, Zou W*. Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer. Cell Metab. 2018;28(1):87-103.e6.

21. Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, Xiao J, Chen X,Xia H, Wu Y, Zhou Z, Guo X, Hu C, Yang C, Cheng X, Chen C*, Qi X*. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128(9):4148-4162.

22.Xia H#, Wang W#, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, Zou W*. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Sci Immunol. 2017;2(17).eaan4631.

23. Guo L, Zhang P, Chen Z,Xia H, Li S, Zhang Y, Kobberup S, Zou W, Lin JD*. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. 2017;127(12):4449-4461.

24. Ge G#,Xia H#, He B, Zhang H, Liu W, Shao M, Wang C, Xiao J, Ge F, Li F, Li Y, Chen C*. Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution. Int J Cancer. 2016;138(3):642-51.

25. Zhang L, Tian R, Zheng H, Pan G, Tuo X,Xia H, Xia X, Pang W, Zheng Y. Translocation of microbes and changes of immunocytes in the gut of rapid‐and slow‐progressor Chinese rhesus macaques infected with SIV mac239. Immunology. 2016;147 (4), 443-452

26. Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, Shao M, You D, Fan Z,Xia H, Liu R, Chen C*. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat Commun. 2015;6:8471.

27.Xia H#, He B#, Wang C, Zhang H, Ge G, Zhang Y, Lv L, Jiao J, Chen C*. PTEN/PIK3CA genes are frequently mutated in spontaneous and medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumours of tree shrews. Eur J Cancer. 2014;50(18):3230-42.

28. Kong Y, Chen J, Zhou Z,Xia H, Qiu MH, Chen C. Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. PloS one. 2014;9 (7), e103760.

29.Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C*. Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem. 2013;288(37):26731-40.

30.Xia H, Wang C, Zhang H, He B, Jiao J, Chen C*. Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis). Zoological Research. 2012;33(1): 55-59.

31. Ma J,Xia H, Zhang G, Han J, Zhang L, Zheng Y. Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques. Cellular & Molecular Immunology. 2012;9 (5), 410-416

32. Li S,Xia H, Dai Z, Zhang G, Fan B, Li M, Wang R, Zheng Y. Dynamics and functions of CD4+CD25high regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239. Archives of virology. 2012;157 (5), 961-967

33. Dai Z, Zhang G, Zhang X,Xia H, Li S, Zheng Y. Theβ2-Microglobulin–Free Heterodimerization of Rhesus Monkey MHC Class IA with Its Normally Spliced Variant Reduces the Ubiquitin-Dependent Degradation of MHC Class IA. The Journal of Immunology. 2012;188 (5), 2285-2296

34.Xia H, Ma J, Zhang G, Han J, Wang J, Zheng Y*. Effect of plasma viremia on apoptosis and immunophenotype of dendritic cells subsets in acute SIVmac239 infection of Chinese rhesus macaques. PLoS One. 2011;6(12):e29036.

35.Xia H, Chen C*. Progress of non-human primate animal models of cancers (Review), Zoological Research. 2011;32(1): 70-80.

36.Xia H, Zhang G, Ma J, Dai Z, Li S, Han J, Zheng Y*. Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques. Retrovirology. 2010;7:102.

37.Xia H, Zhang G, Zheng Y*. Roles of Dendritic Cell in Disease Progression of AIDS Primate Models (Review). Zoological Research. 2010;31(1):57-65.

38.Xia H, Liu H, Zhang G, Zheng Y*. Phenotype and function of monocyte-derived dendritic cells from chinese rhesus macaques. Cell Mol Immunol. 2009;6(3):159-165.

39.Xia H, Zhang G, Wang R, Zheng Y*. The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques. Cell Mol Immunol. 2009;6(6):433-440.

代表性专利

1、夏厚军,唐秋菊,曾繁彬。一种靶向髓系细胞基因编辑的CRISPR-CAS系统及其构建方法。专利号:ZL 202211487740.3,授权日期2025/04/18。

2、王守国,罗木鹏,夏厚军。一类β-咔啉类化合物及其在制备治疗或预防肿瘤疾病的药物中的应用。专利号:ZL202211008258.7,授权日期2023/10/20。

3、陈策实,夏厚军,何保丽,角建林。一种乳头注射慢病毒建立树鼩乳腺癌模型的方法。专利号:ZL201310133542.1,授权日期2015/02/18。

联系方式

电子邮件:xiahoujun@suat-sz.edu.cn

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