EN

师资队伍

范文霞Wenxia Fan

科研助理教授

药学院

邮箱:fanwenxia@suat-sz.edu.cn

世上无难事,只要肯登攀。

个人简介

范文霞,生物化学与分子生物学博士,2012年毕业于中国科学院广州生物医药与健康研究院,研究方向为诱导性多能干细胞。2016年进入广州医科大学呼吸疾病全国重点实验室博士后工作站,从事感染与免疫领域相关的研究。熟练掌握iPSC诱导分化、类器官构建、药物筛选等技术。擅长利用iPSCs作为疾病模型、治疗性细胞的再生、病毒与宿主细胞的相互作用等研究。曾主持和参与多项广州市、广东省、国家级、省部级以及中外合作科研项目。

学习工作经历

学习经历:

2009-2012中国科学院广州生物医药与健康研究院,生物化学与分子生物学专业,博士

2005-2008江西农业大学,微生物学专业,硕士

2008-2012聊城大学,生物工程专业,学士

工作经历:

2025.10-至今 深圳理工大学,药学院,科研助理教授

2025.4-2025.9广州普拜生物科技有限公司,高级研发科学家

2023.4-2025.3广州医科大学附属市八医院,助理研究员

2022.3-2023.3生物岛实验室生物安全部,助理研究员

2016/10-2022/01 广州医科大学呼吸疾病国家重点实验室,博士后&助理研究员

2012.11-2016.07中国科学院广州生物医药与健康研究院,助理研究员

研究领域

干细胞、感染与免疫、抗肿瘤或抗病毒新策略以及基于hiPSCs的CAR-T/CAR-NK的研发。

代表性文章

1.Xiaohan Huang&,Wenxia Fan&, Jing Sun&, Jiaqing Yang, Yanjun Zhang, Qian Wang, Pingchao Li, Yudi Zhang, Shengnan Zhang, Heying Li, Jianhua Wang, Liqiang Feng, Jincun Zhao, Ling Chen, Qu Linbing.SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril.Antiviral Research, 2023 Jul:215:105636. (&共同第一作者)

2.Shuhan Chen, Zhiwei Luo, Carl Ward, David P Ibañez, Hao Liu, Xiaofen Zhong, Narendra K Sharma, Baoming Qin,Wenxia Fan*, Dongye Wang*. Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9.Stem Cell Research. 2020 May;45:101804.(*共同通讯作者)

3.Mazid Md. Abdul; David P. Ibañez; Ping Zhao; Hao Liu; Xiaofen Zhong; Yingying Li; Meng Zhang; Wenjuan Li; Yunpan Li; Carl Ward; Shuhan Chen; Dongye Wang; Baoming Qin; Miguel A. Esteban; Xiwei wang*;Wenxia Fan*; Zhiwei Luo. Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N),Stem Cell Research, 2019.Dec, 41: 101607.(*共同通讯作者)

4.Li W&, Wang XM&,Fan WX&, Zhao P, Chan YC, Chen S, Zhang SQ, Guo XP, Zhang Y, Li YH, Cai JL, Qin DJ , Li XY, Yang JY, Peng TR, Zychlinski D, Hoffmann D, Zhang RS, Deng K, Ng KM, Menten B, Zhong M, Wu JY, Li ZY, Chen YL, Schambach A, Tse HF, Pei DQ *, and Esteban MA*. Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes.Human Molecular Genetics, 2012, 21(1):32-45. (&共同第一作者)

5.Xianmiao Ye&,Xinglong Liu&,Tao Shu,Weiqi Deng,Min Liao,Yali Zheng,Xuehua Zheng,Xiaoyan Zhang,Ting Li,Wenxia Fan,Linbing Qu,Ling Chen*,Feng Li*,Liqiang Feng*. A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice. J Virol 2021 Jun 24;95(14):e0038321.

6.Yunpan Li, David P Ibañez,Wenxia Fan, Ping Zhao, Shuhan Chen, Mazid Md Abdul, Yu Jiang, Lixin Fu, Zhiwei Luo, Zhenhua Liu, Yueli Yang, Jifeng Guo, Giacomo Volpe, Shahzina Kanwal, Dongye Wang, Beisha Tang*, Wenjuan Li*. Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson’s disease patient with mutant DJ-1/PARK7 (p.L10P).Stem Cell Research. 2020 Jul;46:101845.

7.Muqddas Tariq,Hao Liu,David P Ibañez,Yunpan Li,Shuhan Chen,Mengling Jiang,Wenxia Fan,Ping Zhao,Zhiwei Luo,Dongye Wang,Shahzina Kanwal*. Generation of three induced pluripotent stem cell lines from a Parkinson's disease patient with mutant PARKIN (p. C253Y).Stem Cell Research. 2020 May:45:101822.

8.Zhang M, Ibañez DP,Fan W, Liu H, Zhong X, Wang X, Li Y, Md Abdul M, Li W, Li Y, Ward C, Chen S, Wang D, Qin B, Esteban MA, Zhao P*, Luo Z*. Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common isoforms abolished.Stem Cell Research. 2019 Dec;41:101602.

9.Zhao P &, Luo ZW &, Tian WH, Yang JY, Ibáñez DP, Huang Z, Tortorella MD, Esteban MA*,Fan WX. Solving the puzzle of Parkinson's disease using induced pluripotent stem cells.Experimental Biology and Medicine. 2014, 239(11):1421-32.

10.Zhang F, Wang L, Niu X, Li J, Luo J, Feng Y, Yang Y, He P,Fan W, Liang R, Zheng Z, Pan W, Li C, Tan YJ, Yu H, Chen Ling*, Li Pingchao*. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies.Frontiers in Immunology. 2019 Oct 11;10:2426.

11.Zhuang Q&, Li W&, Benda C&, Huang Z, Ahmed T, Liu P, Guo X, Ibañez DP, Luo Z, Zhang M, Abdul MM, Yang Z, Yang J, Huang Y, Zhang H, Huang D, Zhou J, Zhong X, Zhu X, Fu X,Fan W, Liu Y, Xu Y, Ward C, Khan MJ, Kanwal S, Mirza B, Tortorella MD, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP, Esteban MA*.NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.Nature Cell Biology. 2018,20 (4):400-412.

12.Yang J&, Wang Y&, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Cheng LH, Liang G, Huang Z,Fan W, Zhao P, Wang X, Ibañez DP, Luo Z, Li Y, Zhong X, Chen S, Wang D, Li L, Lai L, Qin B, Bao X, Hutchins AP, Siu CW, Huang Y, Esteban MA*, Tse HF*. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.Stem Cell Reports. 2017,14;8(3):605-618.

13.Ji JF*, Sharma V, Qi SX, Guarch ME, Zhao P, Luo ZW,Fan WX, Wang Y, Mbabaali F, Neculai D, Esteban MA, McPherson JD, Batada NN*. Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells.Stem Cell Reports. 2014, 2(1):44-51.

14.Liu LQ&, Xu Y&*, He MH&, Zhang M, Cui FG, Lu L, Yao M, Tian WH, Benda C, Zhuang Q, Huang ZJ, Li W, Li X, Zhao P,Fan WX, Luo ZW, Li Y, Wu YS, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin BM, Bao XC, Yao H, Zhang B, Sun H, Pei DQ, Wang H, Wang J, Esteban MA*. Transcriptional pause release is a rate-limiting step for somatic cell reprogramming.Cell Stem Cell. 2014, 6;15(5):574-88.

联系方式

电子邮箱:fanwenxia@suat-sz.edu.cn

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