张铎，肿瘤生物学博士，现任深圳理工大学药学院特聘正教授、中国科学院深圳先进技术研究院医药所癌症免疫研究中心客座副研究员。国家级青年人才、广东省青年拔尖人才、深圳市“鹏城孔雀计划”特聘岗位B档；主持国家自然科学基金青年项目、深圳市医学研究专项资金青年项目等多项课题。主要研究成果包括揭示了内皮细胞代谢介导的实体肿瘤对CAR-T免疫治疗的耐药性机制，以及开发了内皮细胞特异性脂质纳米颗粒系统、小鼠可示踪CAR-T细胞系统、针对肿瘤组织的高分辨率3D荧光显微方法等创新技术。主要研究方向聚焦于探索肿瘤微环境的免疫抑制机制，并研发新一代针对实体肿瘤的免疫疗法。近年代表性成果发表于Cell Metabolism，Nature Protocols，Nature Cardiovascular Research等期刊。

肿瘤免疫疗法研发；肿瘤微环境的免疫抑制机制；内皮细胞在肿瘤和心血管疾病中的可塑性和代谢调控机制。

2025 第二十七届中国国际高新技术成果交易会，优秀科研成果创新奖

2022 第22届国际血管生物学会议旅行奖

2021 美国心脏协会（AHA）博士生奖学金

1. Liu Y*, Xiang C*, Dai Y, Li C, Okeke MN, Jiang T, Yang X, Assaraf YG, Miao K, Wang Y, Zhang Z,Zhang D^✠, Li Y^✠, Gong P^✠, Zhao Q^✠. Engineered apoptotic vesicle mimetics with tunable“eat-me”signaling precisely regulate tumor-associated macrophages for potentiating cancer immunotherapy.Acta Pharmaceutica Sinica B. 2025 Nov 29; doi:10.1016/j.apsb.2025.11.032.

2.Zhang D, Li AM, Hu G, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, Kahn M, Rhoades SD, Weljie AM, Fuchs SY, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y, Fan Y. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy.Cell Metabolism. 2023 Mar 7;35(3):517-534.e8.

3.Zhang D, Cleveland AH, Krimitza E, Dorsey J, Gong Y, Fan Y. Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy.Nature Protocols.2024 Jan 11.

4. Huang M*, Fan Y*,Zhang D*, Lin MH*, Duan H, El-Mayta R, Zhang L, Qin L, Shewale S, Pei L, Mitchell M, Fan Y^✠, Gong Y^✠. Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction.Nature Cardiovascular Research. 2022 April 13; 1:372--388.

5.Zhang D*, Krimitza E*, Han K, Gong Y, Fan Y. Generation of tracible mouse CAR T cells for syngeneic mouse cancer models.STAR Protocols.2024 Feb 15;5(1):102898.

6. Yang F,Zhang D, Jiang H, Ye J, Zhang L, Bagley SJ, Winkler J, Gong Y, Fan Y. Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy.Science Translational Medicine. 2023 Feb 15;15(683):eabq3558.

7. Huang M,Zhang D, Wu J, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder Z, O'Rourke D, Brem S, Koumenis C, Gong Y, Fan Y. Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma.Science Translational Medicine. 2020 February 26; 12(532):eaay7522-.

8. Yang F*, Akhtar MN*,Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y. An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma.Science Advances.2024 Mar;10(9):eadj4678.

9. Ma W*, Wang Y*, Zhang R*, Yang F*,Zhang D, Huang M, Zhang L, Dorsey JF, Binder ZA, O'Rourke DM, Fraietta J A, Gong Y, Fan Y. Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma.Nature Cancer.2021 Jan; 83--97(2).

电子邮箱：zhangduo@suat-sz.edu.cn