EN

师资队伍

郑植元

科研助理教授

药学院

前海外职称:澳门科技大学 博士

邮箱:zhengzhiyuan@siat-sz.edu.cn

一个人的历史是自己写成的!

个人简介

郑植元,博士,深圳理工大学(筹)药学院助理教授,主要从事靶向实体肿瘤的新药研究,包括天然小分子药物的发现、结构优化与药理活性研究,以CAR-T、TCR-T疗法为代表的基于新型抗肿瘤免疫治疗技术的生物药物研究。

学习工作经历

学习经历:

2017.09 - 2021.08,澳门科技大学,中药质量研究国家重点实验室,中药学,博士

2012.09 - 2015.07,中国科学院大学,中药学,硕士

2008.09 - 2012.07,郑州大学,药学,学士

工作经历:

2024.01至今,深圳理工大学(筹),药学院,科研助理教授

2021.09 - 2023.12,中国科学院深圳先进技术研究院,博士后,助理研究员

2016.06 - 2017.08,澳门科技大学,中药质量研究国家重点实验室,科研助理

2015.07 - 2016.05,河南省医药科学研究院,河南省肝病药理重点实验室,研究实习员

所获荣誉(或科研成果)

主要从事靶向实体肿瘤的小分子药物和工程化细胞药物研究与开发,参与国家自然科学基金重点项目和面上项目、国家重点研发计划项目、澳门科技发展基金项目等,发表论文20余篇,申请发明专利6项,授权3项。

研究领域

1.肿瘤免疫疗法新技术研究;

2.小分子抗肿瘤药物的发现、结构优化与药理活性研究

代表文章

1.Zhiyuan Zheng#, Ting Xu#, Zhiyan Liu,Wenyue Tian,Zhi-Hong Jiang,Guo-Yuan Zhu,Ting Li,Jin Gao,Li-Ping Bai*, Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis,Biomedicine & Pharmacotherapy, 2022, 153, 113319.

2.Zhiyuan Zheng#, Zhongbo Zhou#, Qiulong Zhang, Xiaobo Zhou, Ji Yang, Ming-Rong Yang, Guo-Yuan Zhu, Zhi-Hong Jiang, Ting Li, Qianyu Lin, Li-Ping Bai*, Non-classical cardenolides fromCalotropis giganteaexhibit anticancer effect as HIF-1 inhibitors,Bioorganic Chemistry, 2021, 109, 104740.

3.Zhiyuan Zheng#, Ming Zhang#, Yuancan Xiao, Lixin Wei*, Cen Li*. Effect of Cys, GSH, and pH on Mercury Release from Tibetan MedicineZuotai, β-HgS, and α-HgS in Artificial Gastrointestinal Juices,Biological Trace Element Research, 2018, 184(2):536–545.

4.Zhiyuan Zheng, Yuzhi Du, Ming Zhang, Mingjie Yu, Cen Li, Hongxia Yang, Jing Zhao, Zhenghua Xia, LixinWei*. Study on Content Determination of Lead and Arsenic in Four Traditional Tibetan Medicine Prescription Preparations by Wet Digestion Flow Injection-Hydride Generation-Atomic Absorption Spectrometry,Spectroscopy and Spectral Analysis, 2015, 35(4): 1037‒1042.

5.郑植元,李岑,张明,杨红霞,耿卢婧,李林帅,杜玉枝,魏立新*,含HgS传统药物朱砂和佐太中汞的胃肠道溶出及吸收蓄积研究,中国中药杂志,2015, 40: 2455‒2460.

6. Meixian Liu, Huimin Huang, Xiqing Bian,Zhiyuan Zheng, Na Li, Baoqing Sun∗and Jian-Lin Wu∗, A prospective cohort study of the presence of SARS-CoV-2 in clinical samples from multiple bodily sites: implications for transmission routes of COVID-19,Journal of Bio-X Research, 2022, 5(1): 27-34.

7. Yong Guo#, Jie-Ru Meng#, Jia-Zheng Liu, Ting Xu,Zhi-Yuan Zheng, Zhi-Hong Jiang and Li-Ping Bai*, Synthesis and Biological Evaluation of Honokiol Derivatives Bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones as Potential Viral Entry Inhibitors against SARS-CoV-2,Pharmaceuticals, 2021, 14, 885.

8.Ting Xu,Zhiyuan Zheng, Yong Guo*, Li-Ping Bai*, Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy,European Journal of Medicinal Chemistry, 2020, 205, 112663.

9.Meixian Liu, Na Li*, Yida Zhang,Zhiyuan Zheng, Yue Zhuo, Baoqing Sun, Li-Ping Bai, Mingming Zhang, Ming-Quan Guo, Jian-Lin Wu*, Characterization of covalent protein modification by triclosan in vivo and in vitro via three-dimensional liquid chromatography-mass spectrometry: New insight into its adverse effects,Environment International, 2020, 136, 105423.

10. Xiaobo Zhou#, Yuan Qing Qu#,Zhiyuan Zheng, Betty Yuen Kwan Law, Simon Wing Fai Mok, Zhi-Hong Jiang*, Vincent Kam Wai Wong*, Li-Ping Bai*, Novel dauricine derivatives suppress cancer via autophagy-dependent cell death,Bioorganic Chemistry, 2019, 83: 450‒460.

11.Dongsheng Fan, Ting Li,Zhiyuan Zheng, Guo‑Yuan Zhu, Xiaojun Yao, Zhi‑Hong Jiang*, Li‑Ping Bai*, Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii,Journal of Natural Medicines, 2019, 73:23‒33.

12. Cen Li, Wei Xu, Shengqi Chu,Zhiyuan Zheng, Yuancan Xiao, Linshuai Li, Hongtai Bi, Lixin Wei*, The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicineZuotaiβ-HgS and HgCl2in mouse kidney,Journal of Trace Elements in Medicine and Biology, 2018, 45: 104‒113.

13. Xiaobo Zhou#, Ming Chen#,Zhiyuan Zheng, Guo-Yuan Zhu, Zhi-Hong Jiang* and Li-Ping Bai*, Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity,RSC Advances, 2017, 7, 26921‒26929.

14. Dongsheng Fan, Shuangyan Zhou,Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Ming-Rong Yang, Zhi-Hong Jiang and Li-Ping Bai*, New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii,International Journal of Molecular Sciences, 2017, 18, 147.

联系方式

电子邮件:zhengzhiyuan@siat-sz.edu.cn

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