耿勇，特聘正教授，博士生导师。2007年毕业于中国科学院生物物理研究所，获生物化学博士学位。随后赴美国从事科研工作，2007-2009年在达特茅斯医学院开展博士后研究；2009-2015年在哥伦比亚大学先后任博士后、副研究员。2015-2026年任中国科学院上海药物研究所研究员、课题组组长。2026年起任职深圳理工大学。长期致力于纳米抗体与结构生物学研究。

学习经历：

2003-2007 中国科学院生物物理研究所，生物化学专业，博士

2000-2003 中国药科大学，药物化学专业，硕士

1993-1997 湖北中医药大学，中药专业，学士

工作经历：

2026-至今 深圳理工大学，药学院，特任正教授

2015-2026 中国科学院上海药物研究所，研究员，课题组组长

2013-2015 哥伦比亚大学医学院药理系，助理研究员

2009-2013 哥伦比亚大学医学院药理系，博士后

2007-2009 达特茅斯医学院生物化学系，博士后

1997-2000 湖北医药学院附属太和医院药学部，药剂师

致力于纳米抗体创新药物的研发，结合人工智能辅助蛋白设计与结构生物学可视化技术，系统研究关键靶点的识别机制与构象调控，推动高选择性、高活性的生物治疗分子的发现，为重大疾病提供精准干预策略。目前研究聚焦WNT信号通路的分子机制及纳米抗体的靶向调控。

1.Huarui Qiao#, Fangzheng Hu#, Yiang Wang#, Lu Wang#, Siyu Zhou#, Shaojue Guo#, Yiwen Xu#, Jianfeng Xu, Qianqian Cui, Qilun Yang, H Eric Xu*, Jianwei Zhu*,Yong Geng*; Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling;Nature communications. (2025) 16:6256.

2.Lu Wang#, Fangzheng Hu#, Qianqian Cui#, Huarui Qiao#, Lingyun Li#, Tengjie Geng#, Yuying Li#, Zengchao Sun, Siyu Zhou, Zhongyun Lan, Shaojue Guo, Ying Hu, Jiqiu Wang, Qilun Yang, Zenan Wang*, Yuanyuan Dai*,Yong Geng*; Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling;Nature communications. (2025) 16:362.

3.Zhongyun Zhang#, Lu Wang#, Huarui Qiao#, Haowen Jiang#, Shaojue Guo, Yuying Li, Ningning Zhang, Tengjie Geng, Qianqian Cui, Zhongyun Lan, Jie Hong, Weiqiong Gu, Ruixin Liu, Guang Ning*, Jia Li*, Jiqiu Wang*,Yong Geng*；Cryo-EM structure of the full-length LGR4- RSPOs complex and a targeting nanobody for anti-obesity therapy；Nature communications. (2025) 16:8406

4.Lingyun Li#, Zhongyun Lan#, Huarui Qiao#, Xiangjing Meng#, Ziyang Shi#, Wanting Zhang, Yi'ang Wang, Zengchao Sun, Qianqian Cui, Lu Wang, Siyu Zhou, Fangzheng Hu, Daizhou Zhang*, Yuanyuan Dai*, Hao Chen*,Yong Geng*; Design of NanoBiT-Nanobody-based FGL1 biosensors for early assisted diagnosis of esophageal cancer;Biomaterials. (2025) 320:123286

5.Lu Xia, Haimeng Li, Qinghua Li, Sen Qin, Zifan Tang, Chunyu Yu, Yanhua Liu, Sudun Guan, Feiya Suo, Yu Gao, Lingyun Li, Lin He, Yongsheng Wang, Wenling Han*, Yongfeng Shang*,Yong Geng*, and Luyang Sun*; A CMTM6 Nanobody Overcomes EGFR-TKI Resistance in Non-small Cell Lung Cancer;Advanced Science. (2025), 2410945.

6.Zengchao Sun#, Lu Wang#, Xiyang Li#, Chengpeng Fan#, Jianfeng Xu#, Zhenzhong Shi, Huarui Qiao, Zhongyun Lan, Xin Zhang, Lingyun Li, Xin Zhou,Yong Geng*; An extended conformation of SARS-CoV-2 main protease reveals allosteric targets;Proceedings of the National Academy of Sciences of the United States of America. 2022 Apr;119(15): e2120913119.

7.Xiaochen Chen#, Lu Wang#, Qianqian Cui#, Zhanyu Ding#, Li Han, Yongjun Kou, Wenqing Zhang, Haonan Wang, Xiaomin Jia, Mei Dai, Zhenzhong Shi, Yuying Li, Xiyang Li,Yong Geng*; Structural insights into the activation of human calcium-sensing receptor;eLife. 2021 Sep, 10: e68578.

8.Zhenzhong Shi#, Xiyang Li#, Rui Gong*, Cheng peng Fan*,Yong Geng*; Structural basis of nanobodies neutralizing SARS-CoV-2 variants; Structure. 2022 May; 30 (5):1-14.

9.Hao Zuo#, Ian Glaaser#, Yulin Zhao#, Igor Kurinov#, Lidia Mosyak#, Haonan Wang#, Jonathan Liu#, Jinseo Park, Aurel Frangaj, Emmanuel Sturchler, Ming Zhou, Patricia McDonald,Yong Geng*, Paul A. Slesinger*, Qing R. Fan*; Structural basis for auxiliary subunit KCTD16 regulation of the GABA B receptor;Proceedings of the National Academy of Sciences of the United States of America. 2019 Apr; 116(17):8370-8379.

10.Yong Geng#, Martin Bush, Lidia Mosyak, Feng Wang, Qing R Fan; Structural mechanism of ligand activation in human GABA(B) receptor;Nature. 2013 Dec; 504(7479), 254-259.

11.Yong Geng#, Lidia Mosyak, Igor Kurinov, Hao Zuo, Emmanuel Sturchler, Cheung Cheng, Prakash Subramanyam, Alice P Brown, Sarah C Brennan, Chang Mun, Martin Bush, Yan Chen, Trang X Nguyen, Baohua Cao, Donald D Chang, Matthias Quick, Arthur D Conigrave, Henry M Colecraft, Patricia McDonald, Qing R Fan*; Structural mechanism of ligand activation in human calcium-sensing receptor;eLife. 2016 Jul; 19:5: e13662.

12.Svetlana Burmakina#,Yong Geng#, Yan Chen, and Qing R. Fan*; Heterodimeric coiled-coil interactions of human GABAB receptor;Proceedings of the National Academy of Sciences of the United States of America. 2014 May;111(19):6958-63.

13.Yong Geng#, Dazhi Xiong, Lidia Mosyak, David Malito, Julie Kniazeff, and Qing. R. Fan*; Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2;Nature Neuroscience. 2012 June; 15, 970-978.

14.Zhengtai Ma#, Zengchao Sun,Yong Geng*, Zhaoxin Geng*; Sensitivity-enhanced nanoplasmonic biosensor using direct immobilization of two engineered nanobodies for SARS-CoV-2 spike receptor-binding domain detection;Sensors and Actuators B: Chemical. 2023 May; 15:383:133575.

15.Wanting Zhang#, Tingting Liu#, Man Wu#, Xiaochen Chen#, Xinghai Xu#, Likun Gong*, Peihu Xu*;Yong Geng*; Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1;Acta Pharmacologica Sinica.2021 Nov; 42(11):1921-1929.

16.Xiaomin Jia#, Yiru Long#, Xiaolu Yu#, Likun Gong*,Yong Geng*; Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody;Acta Pharmacologica Sinica. 2023 May; 44 (5):1095-1104.

17.Qianqian Cui, Lu Wang, Yuanyuan Dai*,Yong Geng*; Nanobodies as negative allosteric modulators for human calcium sensing receptor;Biochemical and Biophysical Research Communications. 2024 Feb; 5:695:149401.

18.Zengchao Sun, Lu Wang, Lingyuan Li, Yili Sun, Daizhou Zhang, Xiangxi Meng*, Jianfeng Xu*,Yong Geng*, Yuanyuan Dai*. Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes;Journal of Structural Biology. 2023 Sep; 215(3):107996.

电子邮箱：gengyong@suat-sz.edu.cn