活性多肽/工程化細胞外囊泡在代謝-生殖互作外延至皮肤适应症及代际-跨代调控机制研究与转化应用。

张键，中国科学院特聘研究员，中国科学院大学博士生导师，医药所/能量代谢与生殖研究中心主任，深圳市代谢健康重点实验室副主任，深圳理工大学特聘杰出教授。中国科学院动物研究所生殖生物学国家重点实验室博士，美国斯坦福大学妇产科系博士后，ELIXIR/美国斯坦福大学病理系Scientist。中国科学院“百人计划”入选者并获择优支持，深圳市杰出青年基金获得者，深圳市“孔雀计划”海外高层次人才B类，深圳市“国家级领军人才”，深圳市“科技进步二等奖”第一完成人（2022）。中国妇幼保健协会母胎医学分会副主任委员，中国优生优育协会母婴心血管结构与代谢专业委员会副主任委员，广东省医学教育协会生殖与遗传管理专业委员会副主任委员，深圳市医学会母胎医学分会副主任委员。

发现并分离纯化抑制饮食和降脂功能的多肽：Obestatin和Neuronostatin；发现降雄、抗炎及降脂功能的多肽C-20，合作发现降脂降糖功能的多肽代谢素、筛选获得多个针对皮肤适应症的受体结合活性多肽等。申请功能多肽、拮抗肽、投递系统、皮肤适应症等相关专利135项，授权48项，转移转化许可专利22项，孵化公司2家。在国内外学术刊物（Science, J Hepatology, Adv Sci, J Hazard Mate, J Adv Res, Int J Bioprint , JBC等）发表期刊论文140余篇。为多家杂志审稿人，近年先后承担科技部重大研究计划（十二五）、重点研发计划（十三五）、重点研发计划（十四五）、国自然重点、国自然面上/青年、中科院先导专项A类、中科院百人计划、广东省科技计划、深圳市医学研究重大项目、深圳市杰青、深圳市重大等重大科研项目。

学习经历：

工作经历：

2010/12- 至今：中国科学院深圳先进技术研究院，生物医药与技术研究所，能量代谢与生殖研究中心，中心主任，研究员

2008/06- 2010/12: 美国斯坦福大学/Elixir/PAIRE，妇产科系/病理系,Scientist

2003/06- 2008/06：美国斯坦福大学，博士后

1.中国科学院百人计划（2011）

2.深圳市“科技进步二等奖”（第一完成人）（2022）

3.深圳市“国家级领军人才”(2021)

4.深圳市杰青（2012）

5.深圳市“孔雀计划”海外高层次人才

1.科技部十二五“国家重大科学研究计划”

2.科技部十三五"国家重点研发计划"

3.科技部十四五"国家重点研发计划"

4.中国科学院A类战略性先导科技专项

5.国家自然科学基金面上/青年项目

6.中科院百人计划、广东省科技计划、深圳市医学研究重大项目、深圳市杰青、深圳市重大/重点等多项科研项目

1.Yao W, Zhang L, Wang Z, Yao W, Wu W, Zeng F, Han M, Zhu P, Tao F, Deng F^*,Zhang JV^*, Huang B^*. Association between serum metal exposure in early pregnancy and preterm birth: Mediation by inflammatory blood cell parameters. J Hazard Mater. 2026 Mar 1;505:141560.

2.Zhu Z, Du F, Liu Y, Yang J, Ge L, Xiao T, Li M, Chen J, Tang J^*, Yang Y^*,Zhang JV^*. Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Middle-Age Testicular Macrophages. Adv Sci (Weinh). 2026 Mar;13(14):e15166

3.Ge L, Gao Y, Du F, Ma C, Xiao T, Yang Y, Lei X^*,Zhang JV^*. The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity-Induced Oocyte Maturation Arrest. Adv Sci (Weinh). 2025 Oct;12(38):e05570

4.Dong X^#, Wang H^#, Cai J#, Wang Y, Chai D, Sun Z, Chen J, Li M, Xiao T, Shan C,Zhang JV^*,Yu M^*. ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment. J Adv Res. 2025 Jun;72:197-212

5.Teng B^#, Huang C^#, Cheng CL, Udduttula A, Yu XF, Liu C, Li J, Yao ZY, Long J, Miao LF, Zou C, Chu J,Zhang JV^*,Ren PG^*. Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A. J Hepatol. 2020 Aug;73(2):383-393

6.Cai J X^#, Le AW^#, Han XY, Chen J, Lei XH, Huang C^*,Zhang JV^*. Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation. BMC Biol. 2025 Jul 3;23(1):199

7.Liu Y^#, Liu Y^#, Zhao J, Deng T, Ben Y, Lu R, Zhou X, Yan R, Chen X,Zhang JV^*, Zhou G^*. Subcutaneous injection of genetically engineered exosomes for androgenic alopecia treatment. Front Bioeng Biotechnol. 2025 May 30;13:1614090

8.Ding M, Ding Q, Liu Z, Wang L, Pei K, Hu J, Liao Y^*,Zhang JV^*. TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity. J Orthop Surg Res. 2025 May 17;20(1):478

9.Cai J^#, Han X^#, Peng S, Chen J,Zhang JV^*, Huang C^*. Chemerin facilitates placental trophoblast invasion and spiral artery remodeling through the pentose phosphate pathway. Life Sci. 2025 Jul 15;373:123645

10.Ge L^#, Yang Y^#, Xiao T, Gao Y, Chang W, Du F, Yu M,Zhang JV.Ovarian Endometriosis Accelerates Premature Ovarian Failure and Contributes to Osteoporosis and Cognitive Decline in Aging Mice. Int J Mol Sci. 2025 Apr 2;26(7):3313

11.YANGY Y L^#, ZHAO HS^#, WU M M^#, GE L, WANG M Y, DU F F, XIAO Z L , WANG P P, CHEN J, XIAO T X, REN PG^*, RUAN CS^*,ZHANG J V^*. 3D-printed scaffolds with controlled-releasing compounds for ectopic activation of dormant ovarian follicles. Int J Bioprint. 2025, 11(1), 246–258

12.Ma A^#, Yang Y#, Cao L, Chen L,Zhang JV.FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes. Commun Biol. 2024 Sep 7;7(1):1099

13.Yu M^#, Yang Y^#, Zhao H, Li M, Chen J, Wang B, Xiao T, Huang C, Zhao H, Zhou W^*,Zhang JV^*. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression. Front Pharmacol. 2022 Nov 29;13:985618

14.Zhang Q^#, Xiao Z^#, Lee CL, Duan YG, Fan X, Yeung WSB, Chiu PCN^*,Zhang JV^*. The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy. Front Cell Dev Biol. 2022 May 17;10:883636

15.Li R, Ma C, Xiong Y, Zhao H, Yang Y, Xue L, Wang B, Xiao T, Chen J, Lei X, Ma B^*,Zhang J^*. An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Biomolecules. 2021 Jun 9;11(6):857.

16.Sun LF^#, Yang YL^#, Wang MY, Zhao HS, Xiao TX, Li MX, Wang BB, Huang C, Ren PG^*,Zhang JV^*. Inhibition ofCol6a5Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogenic Mice. Front Cell Dev Biol. 2021 May 24;9:669189

17.Huang C^#, Dai XY^#, Cai JX^#, Chen J, Wang BB, Zhu W, Wang E, Wei W^*,Zhang JV^*. A Screened GPR1 Peptide Exerts Antitumor Effects on Triple-Negative Breast Cancer. Mol Ther Oncolytics. 2020 Aug 25;18:602-612

18.Zhao H^#, Yan D^#, Xiang L^#, Huang C, Li J, Yu X, Huang B, Wang B, Chen J, Xiao T, Ren PG^*,Zhang JV^*. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice. Cell Mol Life Sci. 2019 Jan;76(2):355-367

19.Zhang B^#, Tan L^#, Yu Y^#, Wang B, Chen Z, Han J, Li M, Chen J, Xiao T, Ambati BK, Cai L, Yang Q, Nayak NR,Zhang J^*, Fan X^*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice. Theranostics. 2018 Apr 9;8(10):2765-2781

20.Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science. 2005 Nov 11;310(5750):996-9