张键,研究员,中心主任,中国科学院“百人计划”入选者,深圳市杰出青年基金获得者,深圳市“科技进步二等奖”。
长期从事活性多肽的开发,工程化外泌体靶向投递系统的建立,及其在代谢与生殖,衰老与肿瘤中的基础与转化研究,发现并分离纯化抑制饮食和降脂功能的多肽:Obestatin 和 Neuronostatin;发现降雄、抗炎及降脂功能的多肽C-20,合作发现降脂降糖功能的多肽代谢素、筛选获得多个受体结合活性多肽等,已获得授权专利47项,在国内外学术刊物(Science, J Hepatology, Int J Nanomed,等)发表期刊论文100余篇。为多家杂志审稿人,近5年先后承担国家、中科院、广东省和深圳市项目10余项。
ZHANG J V, REN P G, AVSIAN-KRETCHMER O, LUO C W, RAUCH R, KLEIN C, HSUEH A J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J]. Science, 2005, 310(5750): 996-9.
TENG B#, HUANG C#, CHENG C L, UDDUTTULA A, YU X F, LIU C, LI J, YAO Z Y, LONG J, MIAO L F, ZOU C, CHU J,ZHANG J V*, REN P G*. Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A [J]. J Hepatol, 2020,73(2):383-93.
ZHANG B Z#, TAN L B#, YU Y#, WANG B B, CHEN Z L, HAN J Y, LI M X, CHEN J, XIAO T X, AMBATI B K, CAI L T, YANG Q, NAYAK N R,ZHANG J V *, FAN X J*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice [J]. Theranostics, 2018, 8(10): 2765-81.
ZHAO H S#, YAN D W#, XIANG L#, HUANG C, LI J, YU X F, HUANG B B, WANG B B, CHEN J, XIAO T X, REN P G*,ZHANG J V*. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cell Mol Life Sci, 2019, 76(2): 355-67.
HUANG C,BIN C, CAI J X, CHEN J ,WANG B B, LI MX, ZHOU WEI, WANG J G,ZHANG P F,ZHANG J V*.Chondroitin sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-guided Chemotherapy Against Triple Negative Breast Primary and Lung Metastatic Cancer[J].Int J Nanomed,2022,2022:17,5547—5563.
HUANG C#, DAI X Y#, CAI J X#, CHEN J, WANG B B,ZHU W, WANG E, WEI W*,ZHANG J V*.A screened GPR1 peptide exerts antitumor effects on triple-negative breast cancer[J]. Mol Ther-oncolytics,2020,18:602-12.
YU M, YANG Y L, ZHAO H , LI M X, CHEN J, WANG B B,XIAO T X, HUANG C,ZHAO HS ,ZHOU W,ZHANG J V.Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression[J].Front Pharmacol, 2022,doi: 10.3389/fphar.2022.985618.
ZHANG QQ #,XIAO Z L#, LEE C K, DUAN Y G, FAN X J, YEUNG W S B, CHIU P C N*,ZHANG J V*.The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy[J]. Front Cell Dev Biol, 2022 May 17;10:883636.
SUN LF#, YANG Y L#, WANG M Y, ZHAO H S, XIAO T X, LI M X, WANG B B, HUANG C, REN P G*,ZHANG JV*.Inhibition of Col6a5 improve lipid metabolism disorder in Dihydrotestosterone-induced hyperandrogenic mice [J].Front Cell Dev Biol,2021 ,doi: 10.3389/fcell.2021.669189.
SAMSON W K*#,ZHANG J V#, AVSIAN-KRETCHMER O, CUI K, YOSTEN G L, KLEIN C, LYU R M, WANG Y X, CHEN X Q, YANG J, PRICE C J, HOYDA T D, FERGUSON A V, YUAN X B, CHANG J K, HSUEH A J*. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions [J]. J Biol Chem, 2008, 283(46): 31949-59.