纳米医学与纳米药物

合成生物学与光学诊疗一体

生物医学工程与微纳生物机器人

美国医学与生物工程院会士AIMBE Fellow，国际先进材料协会会士IAAM Fellow，中科院“百人计划”。现为生物医药与技术研究所所长，广东省纳米医药重点实验室主任，中科院深港生物材料联合实验室主任。主要从事纳米医学、微纳生物机器人及光学智能诊疗。已在学术期刊Nature Nanotech, Sci Adv, Cell Reports, JACS, Angew Chem, Adv Mater, Matter等发表论文243篇，H指数69，引用1.7万次，发明专利转化24项。中国化学会第29和30届理事会理事和高级会员，中美纳米医学与纳米生物技术学会理事，IEEE-EMBS生物医学工程学会会员。

学习经历：

199209-199507，厦门大学，物理化学，博士

198909-199207，重庆大学，物理化学，硕士

198509-198907，重庆大学，应用化学，学士

工作经历：

2022-至今，深圳理工大学（筹）药学院，讲席教授

200801- 至今，中国科学院深圳先进技术研究院，研究员

200702-200710，美国Emitech Inc公司，研究科学家

200204-200701，美国宾州州立大学，访问学者

200103-200203，美国莱斯大学，博士后

199905-200102，日本大阪大学，JSPS特别研究员

199706-199902，东南大学，副教授

199509-199706，南京大学，博士后

美国医学与生物工程院会士AIMBE Fellow

国际先进材料协会会士IAAM Fellow

全球前2%顶尖科学家

Chin Chem Lett期刊编委

Prog Biochem Biophys期刊编委

中国化学会第29届和30届理事会理事

中美纳米医学与纳米生物技术学会CASNN理事

中国生物医学工程学会纳米医学与工程分会常务委员

中国生物物理学会纳米生物学分会理事

中科院"百人计划"择优支持

广东省特支计划领军人才

深圳市鹏城学者长期特聘教授

广东省自然科学奖二等奖（第一完成人）

深圳市自然科学奖一等奖（第一完成人）

深圳市自然科学奖二等奖（第一完成人）

1）广东省低成本健康创新团队子课题，2010-2015

2）深圳市癌症纳米技术重点实验室，2010-2012

3）国家科技部“973”项目-纳米重大科学研究计划子课题,量子点标记技术研究病毒侵染过程及宿主应答, 2011-2015

4）广东省纳米医药重点实验室，2013-2025

5）国家科技部港澳台科技合作专项项目，骨科生物活性材料研发及应用，2015-2018

6）广东省自然科学基金研究团队项目，肿瘤纳米精准诊疗研究团队，2016-2021

7）SIAT-HKU-CUHK深港生物材料联合实验室，2018-2028

8）广东省科研事业单位重点领域研发计划，肿瘤光学精准诊疗关键技术研发，2021-2024

9）科技部国家重点研发计划合成生物学专项，智能交互型生物-非生物杂合体系的构建及消化道肿瘤诊疗应用，2023-2028

1.Jianhong Liao, Hong Pan*, Guojun Huang, Han Gong, Ze Chen, Ting Yin, Baozhen Zhang, Tingtao Chen*, Mingbin Zheng*, andLintao Cai*. T cell cascade regulation initiates systemic antitumor immunity through living drug factory of anti-PD-1/IL-12 engineered probiotics.Cell Reports, 2024, 43, 114086.

2.GongchengMa, Musa Dirak, ZhongkeLiu, DaoyongJiang, Yue Wang, ChunbaiXiang, YudingZhang, Yuan Luo, Ping Gong*,Lintao Cai*, SafacanKolemen*, and Pengfei Zhang*.Rechargeable Afterglow Nanotorches for In Vivo Tracing of Cell-Based Microrobots.Angewandte Chemie International Edition, 2024, 136(18), e202400658.

3.Baozhen Zhang, Hong Pan*, Ze Chen, Ting Yin, Mingbin Zheng*,Lintao Cai*. Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy.Science Advances, 2023, 9(8), eadc8978.

4.Xiaofan Tang#, Ye Yang#, Mingbin Zheng#, Ting Yin#, Guojun Huang, Zhengyu Lai, Baozhen Zhang, Ze Chen, Tiantian Xu*, Teng Ma*, Hong Pan*, andLintao Cai*. Magnetic–Acoustic Sequentially Actuated CAR T Cell Microrobots for Precision Navigation and In Situ Antitumor Immunoactivation.Advanced Materials, 2023, 35(18), 2211509.

5.Guojun Huang#, Ting Yin#, Baozhen Zhang, Aiqing Ma, Tianfang Kang, Yiran He, Yanlan Long, Sidi Zheng, Hong Pan*, andLintao Cai*. Cell-based intelligent micro/nanorobots for precise regulation and active bio-therapy.Matter, 2023, 6, 4158–4194.

6.Gongcheng Ma, Zhongke Liu, Chunguang Zhu, Huajie Chen*, Ryan T. K. Kwok, Pengfei Zhang*, Ben Zhong Tang,Lintao Cai*, Ping Gong*. H2O2-Responsive NIR-II AIE Nanobomb for Carbon Monoxide Boosting Low-Temperature Photothermal Therapy.Angewandte Chemie International Edition, 2022, 61(36), 202207213.

7.Xing Yang, Ting Yang, Qiqi Liu, Xiuwen Zhang, Xinghua Yu, Ryan T. K. Kwok, Luo Hai, Pengfei Zhang*, Ben Zhong Tang,Lintao Cai*, Ping Gong*.Biomimetic Aggregation-Induced Emission Nanodots with Hitchhiking Function for T Cell-Mediated Cancer Targeting and NIR-II Fluorescence-Guided Mild-Temperature Photothermal Therapy.Advanced Functional Materials, 2022, 32(45), 2206346.

8.Dandan Meng#, Hong Pan#, Wei He#, Xing Jiang, Zhenguo Liang, Xu Zhang, Xiaoyu Xu, Zixi Wang, Jinling Zheng, Ping Gong*, Wenjun Li*,Lintao Cai*. In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy.Advanced Functional Materials, 2022, 32(29), 2202603.

9.Hong Pan^#, Mingbin Zheng^#, Aiqing Ma, Lanlan Liu,Lintao Cai*. Cell/Bacteria-Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy.Advanced Materials, 2021, 33(50), 2100241.

10.Xiuli Xu^#, Guanjun Deng^#, Zhihong Sun^#, Yuan Luo, Junkai Liu, Xinghua Yu, Yang Zhao, Ping Gong, Guozhen Liu, Pengfei Zhang*, Fan Pan,Lintao Cai*, Ben Zhong Tang*.A Biomimetic Aggregation-Induced Emission Photosensitizer with Antigen-Presenting and Hitchhiking Function for Lipid Droplet Targeted Photodynamic Immunotherapy.Advanced Materials, 2021, 33(33), 2102322.

11.Jiehua Xing^#, Ting Yin^#, Shuiming Li, Tiantian Xu, Aiqing Ma, Ze Chen, Yingmei Luo, Zhengyu Lai, Yingnian Lv, Hong Pan, Ruijing Liang, Xinyu Wu, Mingbin Zheng* andLintao Cai*. Sequential Magneto-Actuated and Optics-Triggered Biomicrorobots for Targeted Cancer Therapy.Advanced Functional Materials, 2021, 31(11), 2008262.

12.Lanlan Liu#, Huamei He#, Zhenyu Luo, Haimei Zhou, Ruijing Liang, Hong Pan, Yifan Ma*, andLintao Cai*. In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple-Negative Breast Cancer.Advanced Functional Materials, 2020, 30, 1910176.

13.Guanjun Deng, Xinghua Peng, Zhihong Sun, Wei Zheng, Jia Yu, Lulu Du, Huajie Chen, Ping Gong*, Pengfei Zhang*,Lintao Cai*, and Ben Zhong Tang*. Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics.ACS Nano, 2020, 14(9), 11452-11462.

14.Y.T.Han, H.Pan, W.J.Li, Z.Chen, A.Q.Ma, T.Yin, R.J.Liang, F.M.Chen, Y.F.Ma, Y.Jin, M.B.Zheng*, B.H.Li*,L.T.Cai*.T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy.Advanced Science,2019, 6(15), 1900251.

15.H.Pan, P.Li, G.F.Li, W.J.Li, B.Hu, H.M.He, Z.Chen, F.F.Wang, L.L.Liu, Y.F.Gong, Y.T.Han, Y.M.Luo, M.B.Zheng, Y.F.Ma*,L.T.Cai*, and Y.Jin*.Glycometabolic Bioorthogonal Chemistry-Guided Viral Transduction for Robust Human T Cell Engineering.Advanced Functional Materials,2019, 29(22), 1807528.

16.G.J.Deng, Z.H.Sun, S.P.Li, X.H.Peng, W.J.Li, L.H.Zhou, Y.F.Ma, P.Gong*, andL.T.Cai*.Cell-Membrane Immunotherapy Based on Natural Killer Cell Membrane Coated Nanoparticles for the Effective Inhibition of Primary and Abscopal Tumor Growth.ACS Nano,2018, 12(12), 12096-12108.

17.Z.K.Chen L.L.Liu,R.J.Liang, Z.Y.Luo, H.M.He, Z.H.Wu, H.Tian, M.B.Zheng*, Y.F.Ma, andL.T.Cai*. Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect.ACS Nano, 2018,12(8), 8633-8645.

18.H. Tian, Z.Y. Luo, L.L. Liu, M.B. Zheng*, Z. Chen, A.Q. Ma, R.J. Liang,Z.Q. Han, C.Y. Lu, andL.T. Cai*. Cancer Cell Membrane-biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance.Adv. Funct. Mater, 2017,27(38),1703197.

19.Ze Chen#, Pengfei Zhao#, Zhenyu Luo#, Mingbin Zheng*, Hao Tian, Ping Gong, Guanhui Gao, Hong Pan, Lanlan Liu, Aiqing Ma, Haodong Cui, Yifan Ma, andULintao Cai*U. Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy.ACS Nano, 2016,10(11), 10049-10057.

20.Xiaobin Xie, Guanhui Gao*, Shendong Kang, Tamaki Shibayama, Yanhua Lei, Duyang Gao andULintao Cai*U. Site-Selective Trimetallic Heterogeneous Nanostructures for Enhanced Electrocatalytic Performance.Adv. Mater.2015,27(37), 5573-5577.

21.Chi Chen#, Pengfei Zhang#, Guanhui Gao, Duyang Gao, Yong Yang, Hong Liu, Yuhui Wang, Ping Gong,UL.T. Cai*U. Near-Infrared-Emitting Two-Dimensional Codes Based on Lattice-Strained Core/(Doped) Shell Quantum Dots with Long Fluorescence Lifetime.Adv. Mater., 2014, 26(36), 6313-6317.

22.Hong Pan#, Pengfei Zhang#, Duyang Gao, Yijuan Zhang, Ping Li, Lanlan Liu, Ce Wang, Hanzhong Wang, Yifan Ma*, andUL.T. Cai*U. Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Conjugated Near-Infrared-Emitting Quantum Dots.ACS Nano, 2014, 8 (6), 5468–5477.

23.Z.H. Sheng#, D.H. Hu#, M.B. Zheng, P.F. Zhao, H.L Liu, D.Y. Gao, P. Gong, G.H. Gao, P.F. Zhang, Y.F. Ma*,ULintao Cai*U. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy.ACS Nano, 2014, 8 (12), 12310–12322.

24.Duyang Gao#, Pengfei Zhang#, Zonghai Sheng, Dehong Hu, Ping Gong, Chi Chen, Qian Wan, Guanhui Gao, andULintao Cai*U. Highly Bright and Compact Alloyed Quantum Rods with Near Infrared Emitting: a Potential Multifunctional Nanoplatform for Multimodal Imaging in vivo.Adv. Funct. Mater., 2014, 24(25), 3897-3905.

25.M.B. Zheng, C.X. Yue, Y.F. Ma, P. Gong, P.F. Zhao, C.F. Zheng, Z.H. Sheng, P.F. Zhang, Z.H. Wang,UL.T. Cai*U. Single-Step Assembly of DOX/ICG Loaded Lipid-Polymer Nanoparticles for Highly Effective Chemo-Photothermal Combination Therapy.ACS Nano, 2013, 7(3), 2056–2067.

26.P.F. Zhang, S.H. Liu, D.Y. Gao, D.H. Hu, P. Gong, Z.H. Sheng, J.Z. Deng, Y.F. Ma, UL.T. Cai*.UClick-Functionalized Compact Quantum Dots Protected by Multidentate- Imidazole Ligands: Conjugation-Ready Nanotags for Living-virus Labeling and Imaging.J. Am. Chem. Soc.,2012,134 (20), 8388–8391.